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Year Number of Results
2017 19
2018 3
2019 1
2024 1

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21 results

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Page 1
2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia.
Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena R, Carcillo JA, Correa R, Drover K, Esper AM, Gershengorn HB, Hammond NE, Jayaprakash N, Menon K, Nazer L, Pitre T, Qasim ZA, Russell JA, Santos AP, Sarwal A, Spencer-Segal J, Tilouche N, Annane D, Pastores SM. Chaudhuri D, et al. Crit Care Med. 2024 May 1;52(5):e219-e233. doi: 10.1097/CCM.0000000000006172. Epub 2024 Jan 19. Crit Care Med. 2024. PMID: 38240492
RATIONALE: New evidence is available examining the use of corticosteroids in sepsis, acute respiratory distress syndrome (ARDS) and community-acquired pneumonia (CAP), warranting a focused update of the 2017 guideline on critical illness-related corticosteroid insufficienc …
RATIONALE: New evidence is available examining the use of corticosteroids in sepsis, acute respiratory distress syndrome (ARDS) and communit …
Nitric oxide-mediated pathways and its role in the degenerative diseases.
Zhang N, Diao Y, Hua R, Wang J, Han S, Li J, Yin Y. Zhang N, et al. Front Biosci (Landmark Ed). 2017 Jan 1;22(5):824-834. doi: 10.2741/4519. Front Biosci (Landmark Ed). 2017. PMID: 27814649 Free article. Review.
These effects are mainly mediated by the reactivity of NO with various reactive oxygen species, which can be countered by antioxidant enzymes. In addition, NO can directly modify biological molecules via S-nitrosylation and lead to altered signaling responses. ...
These effects are mainly mediated by the reactivity of NO with various reactive oxygen species, which can be countered by antioxidant enzyme …
DRMDA: deep representations-based miRNA-disease association prediction.
Chen X, Gong Y, Zhang DH, You ZH, Li ZW. Chen X, et al. J Cell Mol Med. 2018 Jan;22(1):472-485. doi: 10.1111/jcmm.13336. Epub 2017 Aug 31. J Cell Mol Med. 2018. PMID: 28857494 Free PMC article.
Recently, microRNAs (miRNAs) are confirmed to be important molecules within many crucial biological processes and therefore related to various complex human diseases. ...
Recently, microRNAs (miRNAs) are confirmed to be important molecules within many crucial biological processes and therefore related t …
PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIalpha, Inhibits the Growth of Breast Cancer Cells.
Li J, Gao Z, Zhao D, Zhang L, Qiao X, Zhao Y, Ding H, Zhang P, Lu J, Liu J, Jiang H, Luo C, Chen C. Li J, et al. Cancer Res. 2017 Nov 15;77(22):6253-6266. doi: 10.1158/0008-5472.CAN-17-0484. Epub 2017 Aug 21. Cancer Res. 2017. PMID: 28827373
While phosphatidylinositol 4-kinase (PI4KIIalpha) has been identified as a potential target for antitumor therapy, the clinical applications of PI4KIIalpha are limited by a lack of specific inhibitors. Here we report the first small-molecule inhibitor (SMI) of human PI4KII …
While phosphatidylinositol 4-kinase (PI4KIIalpha) has been identified as a potential target for antitumor therapy, the clinical applications …
In silico prediction of drug-target interaction networks based on drug chemical structure and protein sequences.
Li Z, Han P, You ZH, Li X, Zhang Y, Yu H, Nie R, Chen X. Li Z, et al. Sci Rep. 2017 Sep 11;7(1):11174. doi: 10.1038/s41598-017-10724-0. Sci Rep. 2017. PMID: 28894115 Free PMC article.
More specifically, each target protein sequence is transformed as the position-specific scoring matrix (PSSM), in which the evolutionary information is retained; then the local binary pattern (LBP) operator is used to calculate the LBP histogram descriptor. For a drug molecule …
More specifically, each target protein sequence is transformed as the position-specific scoring matrix (PSSM), in which the evolutionary inf …
A three-dimensional ZnII coordination network based on 5,5'-methylenebis(2,4,6-trimethylisophthalic acid) and 2,7-bis(1H-imidazol-1-yl)fluorene: synthesis, structure and luminescence properties.
Chen Z, Sun Y, Liu ZA, Wang N, Yang X, You X, Wang X. Chen Z, et al. Acta Crystallogr C Struct Chem. 2019 Jan 1;75(Pt 1):8-14. doi: 10.1107/S2053229618016285. Epub 2019 Jan 1. Acta Crystallogr C Struct Chem. 2019. PMID: 30601125
A new coordination polymer, namely poly[[diaqua[mu-2,7-bis(1H-imidazol-1-yl)fluorene-kappa(2)N(3):N(3')][mu-5,5'-methylenebis(3-carboxy-2,4,6-trimethylbenzoato)-kappa(2)O(1):O(1')]zinc(II)] hemihydrate], {[Zn(C(23)H(22)O(8))(C(19)H(14)N(4))(H(2)O)(2)].0.5H(2)O}(n), 1, was …
A new coordination polymer, namely poly[[diaqua[mu-2,7-bis(1H-imidazol-1-yl)fluorene-kappa(2)N(3):N(3')][mu-5,5'-methylenebis(3-carboxy-2,4, …
Intracellular imaging of docosanol in living cells by coherent anti-Stokes Raman scattering microscopy.
You S, Liu Y, Arp Z, Zhao Y, Chaney EJ, Marjanovic M, Boppart SA. You S, et al. J Biomed Opt. 2017 Jul 1;22(7):70502. doi: 10.1117/1.JBO.22.7.070502. J Biomed Opt. 2017. PMID: 28742922 Free PMC article.
In keratinocytes, which are the targeted cells of docosanol, the drug molecules appeared to be docking at the periphery of the cell membrane. In contrast, the drug molecules in fibroblasts appeared to accumulate in densely packed punctate regions throughout the cyto …
In keratinocytes, which are the targeted cells of docosanol, the drug molecules appeared to be docking at the periphery of the cell m …
Anti-pandemic influenza A (H1N1) virus potential of catechin and gallic acid.
You HL, Huang CC, Chen CJ, Chang CC, Liao PL, Huang ST. You HL, et al. J Chin Med Assoc. 2018 May;81(5):458-468. doi: 10.1016/j.jcma.2017.11.007. Epub 2017 Dec 26. J Chin Med Assoc. 2018. PMID: 29287704 Free PMC article.
According to our previous study, TSL-1, a fraction of the aqueous extract from the tender leaf of Toonasinensis, has demonstrated antiviral activities against pandemic influenza A (H1N1) through the down-regulation of adhesion molecules and chemokine to prevent viral attac …
According to our previous study, TSL-1, a fraction of the aqueous extract from the tender leaf of Toonasinensis, has demonstrated antiviral …
21 results